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Neurodegenerative disorders are increasingly recognised as disorders of intricate immune-metabolic dysregulation. Among the relevant pathways, the kynurenine pathway (KP) has emerged as a critical intersection between neurochemistry and immune modulation. Research in Alzheimer’s disease (AD), for example, has shown that kynurenic acid (KYNA) levels in cerebrospinal fluid (CSF) are significantly higher in AD patients compared with cognitively healthy controls. Similarly, pathological neuroinflammation has also been observed in multiple system atrophy (MSA) during disease progression. Characterised by autonomic failure, cerebellar ataxia, and parkinsonism, MSA highlights the need for understanding metabolic dysregulation in neurodegenerative disorders. A recent study by Nagao and colleagues (2026)... read more

Chronic stress has profound effects on the body, driven in part by dysregulation of neuroendocrine systems such as cortisol signalling. Elevated cortisol levels have been associated with neurodegenerative diseases, including Alzheimer’s and Parkinson’s diseases, as well as cardiovascular and metabolic disorders. Chronic stress also impacts the immune system, increasing susceptibility to infections and potentially contributing to autoimmune disease. This is particularly relevant given the rising prevalence of mental health conditions worldwide. Against this backdrop, a recent study from Professor Xiaohong Liang’s group investigates the mechanistic link between chronic stress and liver disease. In this study, they demonstrate that chronic stress promotes... read more